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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Ercc1 white adipose tissue

ABSTRACT: Transcriptome analysis of epididymal white adipose tissue (WAT) depots in Ercc1 animals: To further elucidate the role of ERCC1 in WAT we scanned the transcriptome of 15 day old wt and Ercc1 epididymal WAT.

ORGANISM(S): Mus musculus

SUBMITTER: George Garinis

PROVIDER: E-MEXP-3930 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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DNA damage triggers a chronic autoinflammatory response, leading to fat depletion in NER progeria.

Karakasilioti Ismene I Kamileri Irene I Chatzinikolaou Georgia G Kosteas Theodoros T Vergadi Eleni E Robinson Andria Rasile AR Tsamardinos Iannis I Rozgaja Tania A TA Siakouli Sandra S Tsatsanis Christos C Niedernhofer Laura J LJ Garinis George A GA

Cell metabolism 20130901 3

Lipodystrophies represent a group of heterogeneous disorders characterized by loss of fat tissue. However, the underlying mechanisms remain poorly understood. Using mice carrying an ERCC1-XPF DNA repair defect systematically or in adipocytes, we show that DNA damage signaling triggers a chronic autoinflammatory response leading to fat depletion. Ercc1-/- and aP2-Ercc1F/- fat depots show extensive gene expression similarities to lipodystrophic Pparγ(ldi/+) animals, focal areas of ruptured basemen ...[more]

PMID: 24011075

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