Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Huangming Xie
PROVIDER: E-MEXP-1932 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Diabetes 20090202 5
<h4>Objective</h4>We investigated the regulation and involvement of microRNAs (miRNAs) in fat cell development and obesity.<h4>Research design and methods</h4>Using miRNA microarrays, we profiled the expression of >370 miRNAs during adipogenesis of preadipocyte 3T3-L1 cells and adipocytes from leptin deficient ob/ob and diet-induced obese mice. Changes in key miRNAs were validated by RT-PCR. We further assessed the contribution of the chronic inflammatory environment in obese adipose tissue to t ...[more]