Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Julie Sollier
PROVIDER: E-MEXP-41 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Sollier Julie J Lin Waka W Soustelle Christine C Suhre Karsten K Nicolas Alain A Géli Vincent V de La Roche Saint-André Christophe C
The EMBO journal 20040408 9
The Set1 protein of Saccharomyces cerevisiae is a histone methyltransferase (HMTase) acting on lysine 4 of histone H3. Inactivation of the SET1 gene in a diploid leads to a sporulation defect. We have studied various processes that take place during meiotic differentiation in set1delta diploid cells. The absence of Set1 leads to a delay of meiotic S-phase onset, which reflects a defect in DNA replication initiation. The timely induction of meiotic DNA replication does not require the Set1 HMTase ...[more]