Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Antonio Iavarone
PROVIDER: E-MEXP-413 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Lasorella Anna A Stegmüller Judith J Guardavaccaro Daniele D Liu Guangchao G Carro Maria S MS Rothschild Gerson G de la Torre-Ubieta Luis L Pagano Michele M Bonni Azad A Iavarone Antonio A
Nature 20060628 7101
In the developing nervous system, Id2 (inhibitor of DNA binding 2, also known as inhibitor of differentiation 2) enhances cell proliferation, promotes tumour progression and inhibits the activity of neurogenic basic helix-loop-helix (bHLH) transcription factors. The anaphase promoting complex/cyclosome and its activator Cdh1 (APC/C(Cdh1)) restrains axonal growth but the targets of APC/C(Cdh1) in neurons are unknown. Id2 and other members of the Id family are very unstable proteins that are elimi ...[more]