Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of E47 targets in the neuroblastoma cell line SK-N-SH at 8 hours and 20 hours


ABSTRACT: E47 is a basic Helix Loop Helix (bHLH) transcription factor that has important roles in cell fate determination and differentiation of many cell types. In the nervous system E47 heterodimerizes with tissue-specific, pro-neural bHLH transcription factors and activates downstream target genes. To identify the relevant target genes of bHLH transcription factors in neural cells, we performed gene expression profiling of the human neuroblastoma cell line SK-N-SH engineered to acutely express ectopic E47 by an adenoviral vector. The experiments were done at two time points following adenoviral infection, 8 hours and 20 hours. Genes induced by E47 after 8 hours are likely to be direct targets of this transcription factor.

ORGANISM(S): Homo sapiens

SUBMITTER: Antonio Iavarone 

PROVIDER: E-MEXP-413 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth.

Lasorella Anna A   Stegmüller Judith J   Guardavaccaro Daniele D   Liu Guangchao G   Carro Maria S MS   Rothschild Gerson G   de la Torre-Ubieta Luis L   Pagano Michele M   Bonni Azad A   Iavarone Antonio A  

Nature 20060628 7101


In the developing nervous system, Id2 (inhibitor of DNA binding 2, also known as inhibitor of differentiation 2) enhances cell proliferation, promotes tumour progression and inhibits the activity of neurogenic basic helix-loop-helix (bHLH) transcription factors. The anaphase promoting complex/cyclosome and its activator Cdh1 (APC/C(Cdh1)) restrains axonal growth but the targets of APC/C(Cdh1) in neurons are unknown. Id2 and other members of the Id family are very unstable proteins that are elimi  ...[more]

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