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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of p53 knock-out mouse to analyse neural stem cell (neurosphere) prolifieration

ABSTRACT: The effects of gene p53 knock-out on mouse neural stem cell (neurosphere) prolifieration.

INSTRUMENT(S): G2565BA DNA microarray scanner

ORGANISM(S): Mus musculus

SUBMITTER: Monica Nistér

PROVIDER: E-MEXP-483 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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p53 suppresses the self-renewal of adult neural stem cells.

Meletis Konstantinos K Wirta Valtteri V Hede Sanna-Maria SM Nistér Monica M Lundeberg Joakim J Frisén Jonas J

Development (Cambridge, England) 20060101 2

There is increasing evidence that tumors are heterogeneous and that a subset of cells act as cancer stem cells. Several proto-oncogenes and tumor suppressors control key aspects of stem cell function, suggesting that similar mechanisms control normal and cancer stem cell properties. We show here that the prototypical tumor suppressor p53, which plays an important role in brain tumor initiation and growth, is expressed in the neural stem cell lineage in the adult brain. p53 negatively regulates p ...[more]

PMID: 16368933

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