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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of the effect of metformin (50mg/kg,400mg/kg) on gene expression in livers of db/db mice

ABSTRACT: Effect of metformin (50mg/kg,400mg/kg) on gene expression in livers of db/db mice.

ORGANISM(S): Mus musculus

SUBMITTER: KOJI HAYASHI

PROVIDER: E-MEXP-490 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Global gene expression analysis in liver of obese diabetic db/db mice treated with metformin.

Heishi M M Ichihara J J Teramoto R R Itakura Y Y Hayashi K K Ishikawa H H Gomi H H Sakai J J Kanaoka M M Taiji M M Kimura T T

Diabetologia 20060523 7

<h4>Aims/hypothesis</h4>Metformin is widely used as a hypoglycaemic reagent for type 2 diabetes. While the reduction of hepatic gluconeogenesis is thought to be a key effect, the detailed molecular mechanism of action of metformin remains to be elucidated. To gain insight into this, we performed a global gene expression profiling study.<h4>Materials and methods</h4>We performed DNA microarray analysis to study global gene expression in the livers of obese diabetic db/db mice 2 h after a single a ...[more]

PMID: 16752183

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