Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
DISEASE(S): diabetes
SUBMITTER: Leanne Wardleworth
PROVIDER: E-MEXP-515 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Price Sally Amanda SA Zeef Leo Arnoldus Hendrikus LA Wardleworth Leanne L Hayes Andrew A Tomlinson David Richard DR
Journal of neuropathology and experimental neurology 20060701 7
This study aimed to correlate the onset of functional deficits in diabetic neuropathy with changes in gene expression in rat dorsal root ganglia (DRG). After 1, 4, or 8 weeks of streptozotocin-induced diabetes, sensory and motor nerve conduction velocities (NCV) were measured as an indicator of neuropathy and changes in gene expression were measured using Affymetrix oligonucleotide microarrays. No significant changes in NCV were found after 1 week of diabetes, but after 4 and 8 weeks, there was ...[more]