Transcription profiling of Cadmium induced defects in the embryo 5 h after maternal Cd exposure in the absence or presence of Zn pretreatment
Ontology highlight
ABSTRACT:
INSTRUMENT(S): GenePix 4000B [Axon Instruments]
ORGANISM(S): Mus musculus
SUBMITTER: Michael Stigson
PROVIDER: E-MEXP-529 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Cadmium-induced gene expression changes in the mouse embryo, and the influence of pretreatment with zinc.
Kultima Kim K Fernández Estíbaliz L EL Scholz Birger B Gustafson Anne-Lee AL Dencker Lennart L Stigson Michael M
Reproductive toxicology (Elmsford, N.Y.) 20060603 4
Cadmium (Cd) administered to female C57BL/6 mice on gestation day 8 induces a high incidence of anterior neural tube defects (exencephaly). This adverse effect can be attenuated by maternal pretreatment with zinc (Zn). In this study we used replicated microarray analysis and real-time PCR to investigate gene expression changes induced in the embryo 5 and 10h after maternal Cd exposure in the absence or presence of Zn pretreatment. We report nine genes with a transcriptional response induced by C ...[more]
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