Dataset Information
Transcription profiling of mouse wild type cells vs Lmnb1 knockout cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S): ScanArray Express HT
ORGANISM(S): Mus musculus
SUBMITTER: Nigel Saunders
PROVIDER: E-MEXP-538 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Defects in lamin B1 expression or processing affect interphase chromosome position and gene expression.
The Journal of cell biology 20070220 5
Radial organization of nuclei with peripheral gene-poor chromosomes and central gene-rich chromosomes is common and could depend on the nuclear boundary as a scaffold or position marker. To test this, we studied the role of the ubiquitous nuclear envelope (NE) component lamin B1 in NE stability, chromosome territory position, and gene expression. The stability of the lamin B1 lamina is dependent on lamin endoproteolysis (by Rce1) but not carboxymethylation (by Icmt), whereas lamin C lamina stabi ...[more]
