Transcription profiling of 5 mouse strains liver, kidney and testis to identify the contribution of normal variation and genetic background to mammalian gene expression
Ontology highlight
ABSTRACT:
INSTRUMENT(S): GenePix 4000A [Axon Instruments]
ORGANISM(S): Mus musculus
SUBMITTER: Denise Mauldin
PROVIDER: E-MEXP-568 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The contributions of normal variation and genetic background to mammalian gene expression.
Pritchard Colin C Coil David D Hawley Sarah S Hsu Li L Nelson Peter S PS
Genome biology 20060331 3
<h4>Background</h4>Qualitative and quantitative variability in gene expression represents the substrate for external conditions to exert selective pressures for natural selection. Current technologies allow for some forms of genetic variation, such as DNA mutations and polymorphisms, to be determined accurately on a comprehensive scale. Other components of variability, such as stochastic events in cellular transcriptional and translational processes, are less well characterized. Although potenti ...[more]
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