Transcription profiling of adherent and non-adherent human hematopoietic progenitor cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Wolfgang Wagner
PROVIDER: E-MEXP-586 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Adhesion of hematopoietic progenitor cells to human mesenchymal stem cells as a model for cell-cell interaction.
Wagner Wolfgang W Wein Frederik F Roderburg Christoph C Saffrich Rainer R Faber Anne A Krause Ulf U Schubert Mario M Benes Vladimir V Eckstein Volker V Maul Holger H Ho Anthony D AD
Experimental hematology 20070201 2
<h4>Objective</h4>The significant role of direct contact between hematopoietic progenitor cells (HPC) and the cellular microenvironment for maintaining "stemness" has been demonstrated. Human mesenchymal stem cell (MSC) feeder layers represent a surrogate model for this interaction. Specific adhesion molecules are responsible for this cell-cell contact.<h4>Methods</h4>To define cell-cell contact between HPC and MSC, we have studied adhesive interaction of various fractions of HPC by using a nove ...[more]
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