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Transcription profiling of C. elegans sma-9 and dbl-1 gene knock-outs

ABSTRACT: Experiments performed to determine target genes of sma-9 and DBL-1 signaling

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Ling Yu

PROVIDER: E-MEXP-687 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptional repressor and activator activities of SMA-9 contribute differentially to BMP-related signaling outputs.

Liang Jun J Yu Ling L Yin Jianghua J Savage-Dunn Cathy C

Developmental biology 20070303 2

In the nematode Caenorhabditis elegans, the BMP-related growth factor DBL-1 regulates body size and male tail morphogenesis via a conserved receptor/Smad signaling pathway. Smads are transcription factors, but rely on transcription cofactors for appropriate regulation of target genes in response to TGF-beta- and BMP-related signals. In the DBL-1 pathway, sma-9 encodes multiple zinc finger transcription factors homologous to Drosophila Schnurri, which functions in Dpp/BMP signaling. We have studi ...[more]

PMID: 17397820

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