Transcription profiling of four mouse tissues following acute caloric restriction
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Nicola Kerrison
PROVIDER: E-MEXP-748 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice.
Selman Colin C Kerrison Nicola D ND Cooray Anisha A Piper Matthew D W MD Lingard Steven J SJ Barton Richard H RH Schuster Eugene F EF Blanc Eric E Gems David D Nicholson Jeremy K JK Thornton Janet M JM Partridge Linda L Withers Dominic J DJ
Physiological genomics 20060801 3
Caloric restriction (CR) increases healthy life span in a range of organisms. The underlying mechanisms are not understood but appear to include changes in gene expression, protein function, and metabolism. Recent studies demonstrate that acute CR alters mortality rates within days in flies. Multitissue transcriptional changes and concomitant metabolic responses to acute CR have not been described. We generated whole genome RNA transcript profiles in liver, skeletal muscle, colon, and hypothalam ...[more]
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