Transcription profiling of bursa of Fabricius from genetically resistant and susceptible chickens infected with Infectious Bursal Disease Virus (IBDV)
Ontology highlight
ABSTRACT:
INSTRUMENT(S): GenePix Personal 4100A [Axon Instruments]
ORGANISM(S): Gallus gallus
DISEASE(S): infected with IBDV strain F52/70
SUBMITTER: Mounira Chelbi-Alix
PROVIDER: E-MEXP-756 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Transcriptional profiling reveals a possible role for the timing of the inflammatory response in determining susceptibility to a viral infection.
Ruby Thomas T Whittaker Catherine C Withers David R DR Chelbi-Alix Mounira K MK Morin Veronique V Oudin Anne A Young John R JR Zoorob Rima R
Journal of virology 20060901 18
Using a novel cDNA microarray prepared from sources of actively responding immune system cells, we have investigated the changes in gene expression in the target tissue during the early stages of infection of neonatal chickens with infectious bursal disease virus. Infections of two lines of chickens previously documented as genetically resistant and sensitive to infection were compared in order to ascertain early differences in the response to infection that might provide clues to the mechanism ...[more]
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