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Transcription profiling of mouse embryonic stem cell differentiation following treatment with DKK1

ABSTRACT: Assessed effect of DKK1 treatment on gene expression during the first four days of ES cell differentiation in serum containing medium.

ORGANISM(S): Mus musculus

SUBMITTER: R. Coleman Lindsley

PROVIDER: E-MEXP-759 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes.

Jenner Richard G RG Townsend Michael J MJ Jackson Ian I Sun Kaiming K Bouwman Russell D RD Young Richard A RA Glimcher Laurie H LH Lord Graham M GM

Proceedings of the National Academy of Sciences of the United States of America 20091005 42

Upon detection of antigen, CD4(+) T helper (Th) cells can differentiate into a number of effector types that tailor the immune response to different pathogens. Alternative Th1 and Th2 cell fates are specified by the transcription factors T-bet and GATA-3, respectively. Only a handful of target genes are known for these two factors and because of this, the mechanism through which T-bet and GATA-3 induce differentiation toward alternative cell fates is not fully understood. Here, we provide a geno ...[more]

PMID: 19805038

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Transcription profiling of mouse ES cells bearing a targeted, doxycycline inducible Mesp1 transgene were differentiated in the absence or presence of DKK1

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2008-10-18 | E-GEOD-5976 | biostudies-arrayexpress

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