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Transcription profiling of synectin knock-out mouse primary endothelial cells before and after FGF2 induction

ABSTRACT: Transcriptional regulatory effects of synectin deletion in murine primary endothelial cells both before and after FGF2 induction.

INSTRUMENT(S): GenePix Professional 4200A [Axon Instruments]

ORGANISM(S): Mus musculus

SUBMITTER: Kimberly Smith

PROVIDER: E-MEXP-820 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Synectin-dependent gene expression in endothelial cells.

Lanahan Anthony A AA Chittenden Thomas W TW Mulvihill Eileen E Smith Kimberly K Schwartz Stephen S Simons Michael M

Physiological genomics 20060829 3

Synectin (GIPC1), a receptor scaffold protein, has been isolated by our laboratory as a syndecan-4 cytoplasmic domain binding partner that regulates important aspects of cell motility (Gao Y, Li M, Chen W, Simons M. J Cell Physiol 184: 373-379, 2000; Tkachenko E, Elfenbein A, Tirziu D, Simons M. Circ Res 98: 1398-1404, 2006). Moreover, synectin plays a major role in arterial morphogenesis and in growth factor signaling in arterial endothelial cells by regulating Rac1 activity (Chittenden TW, Cla ...[more]

PMID: 16940428

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