Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of mouse RAG1 knockout CD4+ T cells to investigate the effect of absence of interaction with MHC class II on memory CD4 T cells


ABSTRACT: Effect of absence of interaction with MHC class II on memory CD4 T cells

ORGANISM(S): Mus musculus

SUBMITTER: Brigitta Stockinger 

PROVIDER: E-MEXP-890 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

Noncognate interaction with MHC class II molecules is essential for maintenance of T cell metabolism to establish optimal memory CD4 T cell function.

De Riva Alessandra A   Bourgeois Christine C   Kassiotis George G   Stockinger Brigitta B  

Journal of immunology (Baltimore, Md. : 1950) 20070501 9


CD4 memory T cells surviving in the absence of MHC class II contact lose their characteristic memory function. To investigate the mechanisms underlying the impaired function of memory T cells in the absence of MHC class II molecules, we analyzed gene expression profiles of resting memory T cells isolated from MHC class II-competent or -deficient hosts. The analysis focused on five transcripts related to T cell activation, metabolism, and survival that are underexpressed in resting memory T cells  ...[more]

Similar Datasets

2014-10-17 | E-GEOD-58288 | biostudies-arrayexpress
2014-10-17 | E-GEOD-58289 | biostudies-arrayexpress
2014-10-16 | E-GEOD-58293 | biostudies-arrayexpress
2014-04-05 | E-GEOD-56514 | biostudies-arrayexpress
2021-10-20 | E-MTAB-9572 | biostudies-arrayexpress
2021-10-20 | E-MTAB-10798 | biostudies-arrayexpress
2010-01-14 | E-GEOD-19904 | biostudies-arrayexpress
2021-10-20 | E-MTAB-9574 | biostudies-arrayexpress
2024-08-30 | E-MTAB-13718 | biostudies-arrayexpress
2024-01-26 | PXD039035 | Pride