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Transcription profiling of mouse RAG1 knockout CD4+ T cells to investigate the effect of absence of interaction with MHC class II on memory CD4 T cells

ABSTRACT: Effect of absence of interaction with MHC class II on memory CD4 T cells

ORGANISM(S): Mus musculus

SUBMITTER: Brigitta Stockinger

PROVIDER: E-MEXP-890 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Noncognate interaction with MHC class II molecules is essential for maintenance of T cell metabolism to establish optimal memory CD4 T cell function.

De Riva Alessandra A Bourgeois Christine C Kassiotis George G Stockinger Brigitta B

Journal of immunology (Baltimore, Md. : 1950) 20070501 9

CD4 memory T cells surviving in the absence of MHC class II contact lose their characteristic memory function. To investigate the mechanisms underlying the impaired function of memory T cells in the absence of MHC class II molecules, we analyzed gene expression profiles of resting memory T cells isolated from MHC class II-competent or -deficient hosts. The analysis focused on five transcripts related to T cell activation, metabolism, and survival that are underexpressed in resting memory T cells ...[more]

PMID: 17442930

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