Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Brigitta Stockinger
PROVIDER: E-MEXP-890 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
De Riva Alessandra A Bourgeois Christine C Kassiotis George G Stockinger Brigitta B
Journal of immunology (Baltimore, Md. : 1950) 20070501 9
CD4 memory T cells surviving in the absence of MHC class II contact lose their characteristic memory function. To investigate the mechanisms underlying the impaired function of memory T cells in the absence of MHC class II molecules, we analyzed gene expression profiles of resting memory T cells isolated from MHC class II-competent or -deficient hosts. The analysis focused on five transcripts related to T cell activation, metabolism, and survival that are underexpressed in resting memory T cells ...[more]