Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mammary glands from wild type and Akt1 knock out lactating mice at day 9 after parturition


ABSTRACT: A comparison of gene expression in the mammary gland of lactating mice at day 9 after parturition between Akt -/- and wildtype individuals.

ORGANISM(S): Mus musculus

SUBMITTER: Douglas Stairs 

PROVIDER: E-MEXP-891 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


The metabolic demands and synthetic capacity of the lactating mammary gland exceed that of any other tissue, thereby providing a useful paradigm for understanding the developmental regulation of cellular metabolism. By evaluating mice bearing targeted deletions in Akt1 or Akt2, we demonstrate that Akt1 is specifically required for lactating mice to synthesize sufficient quantities of milk to support their offspring. Whereas cellular proliferation, differentiation, and apoptosis are unaffected, l  ...[more]

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