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Transcription profiling of Neisseria meningitidis knock out mutant of snC transcriptional regulator compared to parent strains

ABSTRACT: Knock out mutant of asnC transcriptional regulator (NMB0573) in N. meningitidis MC58 compared to parent strains (capsule deletion mutant) grown in normal bacterial solid media plate conditions.

INSTRUMENT(S): ScanArray Express HT

ORGANISM(S): Neisseria meningitidis

SUBMITTER: Nigel Saunders 

PROVIDER: E-MEXP-925 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The structure and transcriptional analysis of a global regulator from Neisseria meningitidis.

Ren Jingshan J   Sainsbury Sarah S   Combs Susan E SE   Capper Richard G RG   Jordan Philip W PW   Berrow Nick S NS   Stammers David K DK   Saunders Nigel J NJ   Owens Raymond J RJ  

The Journal of biological chemistry 20070320 19

Neisseria meningitidis, a causative agent of bacterial meningitis, has a relatively small repertoire of transcription factors, including NMB0573 (annotated AsnC), a member of the Lrp-AsnC family of regulators that are widely expressed in both Bacteria and Archaea. In the present study we show that NMB0573 binds to l-leucine and l-methionine and have solved the structure of the protein with and without bound amino acids. This has shown, for the first time that amino acid binding does not induce s  ...[more]

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