Transcription profiling by array of methamphetamine (METH)-treated rats with high or low behavioural responses against saline-treated controls
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Paul Shilling
PROVIDER: E-MEXP-948 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Differential regulation of immediate-early gene expression in the prefrontal cortex of rats with a high vs low behavioral response to methamphetamine.
Shilling Paul D PD Kuczenski Ronald R Segal David S DS Barrett Thomas B TB Kelsoe John R JR
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060719 11
Methamphetamine (METH) administration mimics many of the symptoms of mania and can produce psychosis after chronic use. Both rodents and man display interindividual variation in response to METH. The molecular mechanisms underlying these differences might be relevant to both stimulant addiction and endogenous psychosis. We treated 50 Sprague-Dawley rats acutely with METH (4.0 mg/kg) and 10 control rats with saline, and measured their behavior for 3 h after drug administration. Animals were divid ...[more]
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