Transcription profiling of C.elegans RNAi defective mutants of rde-1 and rde-4
Ontology highlight
ABSTRACT:
ORGANISM(S): Caenorhabditis elegans
SUBMITTER: Brenda Bass
PROVIDER: E-MEXP-956 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genes misregulated in C. elegans deficient in Dicer, RDE-4, or RDE-1 are enriched for innate immunity genes.
Welker Noah C NC Habig Jeffrey W JW Bass Brenda L BL
RNA (New York, N.Y.) 20070525 7
We describe the first microarray analysis of a whole animal containing a mutation in the Dicer gene. We used adult Caenorhabditis elegans and, to distinguish among different roles of Dicer, we also performed microarray analyses of animals with mutations in rde-4 and rde-1, which are involved in silencing by siRNA, but not miRNA. Surprisingly, we find that the X chromosome is greatly enriched for genes regulated by Dicer. Comparison of all three microarray data sets indicates the majority of Dice ...[more]
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