Dataset Information
Transcription profiling of C. elegans dcr-1, unc-32 homozygous mutants vs. coiling unc-32 (wild type) to investidate interference synthesis of small developmental RNAs
Ontology highlight
ABSTRACT:
Wormbase concise description of dcr-1 (DiCer Related): The dcr-1 gene encodes a bidentate ribonuclease that is homologous to E. coli RNAse III; dcr-1 is required both for RNA interference and for synthesis of small developmental RNAs; DCR-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to DCR-1 for endonucleolytic processing.
ORGANISM(S): Caenorhabditis elegans
SUBMITTER: Brenda Bass
PROVIDER: E-MEXP-957 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genes misregulated in C. elegans deficient in Dicer, RDE-4, or RDE-1 are enriched for innate immunity genes.
RNA (New York, N.Y.) 20070525 7
We describe the first microarray analysis of a whole animal containing a mutation in the Dicer gene. We used adult Caenorhabditis elegans and, to distinguish among different roles of Dicer, we also performed microarray analyses of animals with mutations in rde-4 and rde-1, which are involved in silencing by siRNA, but not miRNA. Surprisingly, we find that the X chromosome is greatly enriched for genes regulated by Dicer. Comparison of all three microarray data sets indicates the majority of Dice ...[more]
