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Transcription profiling of ovarium cancer samples from patients with tumors of different stages and sensitivity to platinum chemotherapy treatment


ABSTRACT: We investigated whether prognostic information is reflected in the expression patterns of ovarian carcinoma samples. RNA obtained from seven FIGO stage I without recurrence, seven platin-sensitive advanced-stage (III or IV), and six platin-resistant advanced-stage ovarian tumors was hybridized on a complementary DNA microarray with 21,372 spotted clones. The results revealed that a considerable number of genes exhibit nonaccidental differential expression between the different tumor classes. Principal component analysis reflected the differences between the three tumor classes and their order of transition. Using a leave-one-out approach together with least squares support vector machines, we obtained an estimated classification test accuracy of 100% for the distinction between stage I and advanced-stage disease and 76.92% for the distinction between platin-resistant versus platin-sensitive disease in FIGO stage III/IV. These results indicate that gene expression patterns could be useful in clinical management of ovarian cancer.
KEYWORDS: clinical, FIGO stage, microarrays, ovarian cancer, platin resistance.

INSTRUMENT(S): Generation III Scanner

ORGANISM(S): Homo sapiens

DISEASE(S): ovarian tumor

SUBMITTER: Paul Van Hummelen 

PROVIDER: E-MEXP-979 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Predicting the clinical behavior of ovarian cancer from gene expression profiles.

De Smet F F   Pochet N L M M NL   Engelen K K   Van Gorp T T   Van Hummelen P P   Marchal K K   Amant F F   Timmerman D D   De Moor B L R BL   Vergote I B IB  

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20060101


We investigated whether prognostic information is reflected in the expression patterns of ovarian carcinoma samples. RNA obtained from seven FIGO stage I without recurrence, seven platin-sensitive advanced-stage (III or IV), and six platin-resistant advanced-stage ovarian tumors was hybridized on a complementary DNA microarray with 21,372 spotted clones. The results revealed that a considerable number of genes exhibit nonaccidental differential expression between the different tumor classes. Pri  ...[more]

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