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Transcription profiling of brain from mice with multiple sclerosis, Alzheimers disease and permanent mid-cerebral artery occlusion from stroke to compare of gene expression changes characterizing these three different central nervous system pathologies


ABSTRACT: Three mouse models of human central nervous system pathologies were selected for analyzing gene expression changes compared to wild type normal brain. The selected models are: TgAPP23 for Alzheimerメs disease (see Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.H., Mistl, C., Rothacher, S., Ledermann, B., B?rki, K., Frey, P., Paganetti, P.A., Waridel, C., Calhoun, M.E., Jucker, M., Probst, A., Staufenbiel, M. and Sommer, B. (1997) Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. PNAS 94, 13287-13292), Tg6074 for multiple sclerosis (see Akassoglou K, Bauer J, Kassiotis G, Pasparakis M, Lassmann H, Kollias G and Probert L. (1998). Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy. Am J Pathol. 153, 801-813) and permanent mid-cerebral artery occlusion for stroke (see Welsh, F.A., Sakamoto, T., McKee, A.E. and Sims, R.E. (1987) Effect of lactacidosis on pyridine nucleotide stability during ischemia in mouse brain. J Neurochem. 49, 846-851). Trangenic mice were grown to appropriate age, so that they would manifest the symptoms of disease or disease was induced by a surgical procedure to adult mice. Mice were sacrificed and half brains were removed at selected time points after disease onset for RNA extraction and subsequent array hybridization.

ORGANISM(S): Mus musculus

DISEASE(S): multiple sclerosis

SUBMITTER: Vivian Tseveleki 

PROVIDER: E-MTAB-1 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Comparative gene expression analysis in mouse models for multiple sclerosis, Alzheimer's disease and stroke for identifying commonly regulated and disease-specific gene changes.

Tseveleki Vivian V   Rubio Renee R   Vamvakas Sotiris-Spyros SS   White Joseph J   Taoufik Era E   Petit Edwige E   Quackenbush John J   Probert Lesley L  

Genomics 20100507 2


The brain responds to injury and infection by activating innate defense and tissue repair mechanisms. Working upon the hypothesis that the brain defense response involves common genes and pathways across diverse pathologies, we analysed global gene expression in brain from mouse models representing three major central nervous system disorders, cerebral stroke, multiple sclerosis and Alzheimer's disease compared to normal brain using DNA microarray expression profiling. A comparison of dysregulat  ...[more]

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