Exosomal miRNA profile of physical activity as preventive lifestyle intervention
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ABSTRACT: Emerging evidence suggests that circulating exosomes mediate some of the beneficial effects of exercise via the transfer of microRNAs between tissues. However, the impact of short-term (0.5 year in this study) and long-term (25+ years in this study) regular bouts of exercise on circulating exosomal microRNAs (exomiRs) remains unknown. Our aim was to elucidate the prevention pattern of exomiRs and their targeted pathways. Therefore, in the present study we analyzed serum exomiR expression in healthy young, sedentary participants (n=14) at baseline and following a half year-long moderate-intensity regular exercise training. We also analyzed serum exomiR expression in older, healthy trained participants (seniors, n=11) who engaged in endurance activities for at least 25 years. Following the isolation and enrichment of serum exosomes their exomiR levels were determined using the amplification-free Nanostring platform.
ORGANISM(S): Homo sapiens
SUBMITTER: Kitti Garai
PROVIDER: E-MTAB-10067 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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