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RNA-Seq analysis of Gestational Trophoblastic Diseases

ABSTRACT: Purpose was to determine whether varying gestational trophoblastic disease samples exhibit differences in RNA expression and fusion transcripts.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Homo sapiens

SUBMITTER: Gavin Oliver

PROVIDER: E-MTAB-10321 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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LPCAT1-TERT fusions are uniquely recurrent in epithelioid trophoblastic tumors and positively regulate cell growth.

Oliver Gavin R GR Marcano-Bonilla Sofia S Quist Jonathan J Tolosa Ezequiel J EJ Iguchi Eriko E Swanson Amy A AA Hoppman Nicole L NL Schwab Tanya T Sigafoos Ashley A Prodduturi Naresh N Voss Jesse S JS Knight Shannon M SM Zhang Jin J Fadra Numrah N Urrutia Raul R Zimmerman Michael M Egan Jan B JB Bilyeu Anthony G AG Jen Jin J Veras Ema E Al-Safi Rema'a R Block Matthew M Kerr Sarah S Fernandez-Zapico Martin E ME Schoolmeester John K JK Klee Eric W EW

PloS one 20210525 5

Gestational trophoblastic disease (GTD) is a heterogeneous group of lesions arising from placental tissue. Epithelioid trophoblastic tumor (ETT), derived from chorionic-type trophoblast, is the rarest form of GTD with only approximately 130 cases described in the literature. Due to its morphologic mimicry of epithelioid smooth muscle tumors and carcinoma, ETT can be misdiagnosed. To date, molecular characterization of ETTs is lacking. Furthermore, ETT is difficult to treat when disease spreads b ...[more]

PMID: 34033669

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