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ScRNA-seq of human fetal lung explants with R-SPONDIN Inhibition and human fetal lung primary tissue

ABSTRACT: Here, we used single cell RNA-sequencing (scRNA-seq) to profile 13-week post-conception distal human fetal lung explants cultured in an air liquid interface system and treated with an LGR5 ectodomain adenovirus that inhibits R-Spondin function or control adenovirus. A third, non-infected, condition was also sequenced. We also performed scRNA-seq on distal human fetal lung tissue from an 8.4-week post-conception biological specimen. Diverse cell lineages were captured in all data sets, and include epithelium, mesenchyme, immune, neurons, and endothelium.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER: Renee Hein

PROVIDER: E-MTAB-10662 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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