BRAT1 Links Integrator and Defective RNA Processing with Neurodegeneration
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ABSTRACT: We have identified differentially expressed genes and defects in processing of UsnRNAs in BRAT1-deficient and BRAT1-mutated patient cells by RNA-sequencing and BRAT1 as a structural and functional component of Integrator, linking defects in this critical endonuclease complex with hereditary neurodegenerative disease.
INSTRUMENT(S): NextSeq 500
ORGANISM(S): Homo sapiens
SUBMITTER: Hana Hanzlikova
PROVIDER: E-MTAB-10750 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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