Unknown,Transcriptomics,Genomics

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BRAT1 Links Integrator and Defective RNA Processing with Neurodegeneration


ABSTRACT: We have identified differentially expressed genes and defects in processing of UsnRNAs in BRAT1-deficient and BRAT1-mutated patient cells by RNA-sequencing and BRAT1 as a structural and functional component of Integrator, linking defects in this critical endonuclease complex with hereditary neurodegenerative disease.

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Homo sapiens

SUBMITTER: Hana Hanzlikova 

PROVIDER: E-MTAB-10750 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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