RNA-seq analysis comparing gene expression between mbk-1(-) and mbk-1(+) strains in daf-2(+), daf-2(-), glp-1(+) and glp-1(-) background

ABSTRACT: To identify genes whose expression in Caenorhabditis elegans is regulated by mbk-1 (ortholog of the human protein kinase DYRK1A implicated in Down syndrome) during adulthood, we performed whole transcriptome RNA-sequencing (RNA-seq) on mbk-1(+) and mbk-1(-) worms. To further account for the influence of genetic background on mbk-1 function, these experiments were conducted in long-lived insulin-receptor defective [daf-2(-)] or germline stem cell [GSC] deficient [glp-1(-), i.e. GSC(-)] strains, as well as in corresponding [i.e daf-2(+) or glp-1(+)/GSC(+)] control strains.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Hildegard Mack 

PROVIDER: E-MTAB-10898 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress