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Characterisation of the blood RNA host response underpinning severity in COVID-19 patients

ABSTRACT: Infection with SARS-CoV-2 has highly variable clinical manifestations, ranging from asymptomatic infection through to life-threatening disease. Host whole blood transcriptomics can offer unique insights into the biological processes underpinning infection and disease, as well as severity. We performed whole blood RNA-Sequencing of individuals with varying degrees of COVID-19 severity. We used differential expression analysis and pathway enrichment analysis to explore how the blood transcriptome differs between individuals with mild, moderate, and severe COVID-19, performing pairwise comparisons between groups.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER: Heather Jackson

PROVIDER: E-MTAB-10926 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Diagnosis of multisystem inflammatory syndrome in children (MIS-C) by a whole-blood transcriptional signature

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