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Single cell RNAseq of ankylosing spondylitis lymphocytes from peripheral blood and synovial fluid

ABSTRACT: Single-cell transcriptome of >55,000 cells multiplexed into 4 channels obtained from peripheral blood and synovial fluid of two patients with HLA-B27+ ankylosing spondylitis,.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Homo sapiens

SUBMITTER: Davide Simone

PROVIDER: E-MTAB-10948 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fates.

Simone Davide D Penkava Frank F Ridley Anna A Sansom Stephen S Al-Mossawi M Hussein MH Bowness Paul P

Communications biology 20211214 1

Regulatory T cells (Tregs) play an important role in controlling inflammation and limiting autoimmunity, but their phenotypes at inflammatory sites in human disease are poorly understood. We here analyze the single-cell transcriptome of >16,000 Tregs obtained from peripheral blood and synovial fluid of two patients with HLA-B27+ ankylosing spondylitis and three patients with psoriatic arthritis, closely related forms of inflammatory spondyloarthritis. We identify multiple Treg clusters with dist ...[more]

PMID: 34907325

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