Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 4000
ORGANISM(S): Homo sapiens
SUBMITTER: Davide Simone
PROVIDER: E-MTAB-10948 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Simone Davide D Penkava Frank F Ridley Anna A Sansom Stephen S Al-Mossawi M Hussein MH Bowness Paul P
Communications biology 20211214 1
Regulatory T cells (Tregs) play an important role in controlling inflammation and limiting autoimmunity, but their phenotypes at inflammatory sites in human disease are poorly understood. We here analyze the single-cell transcriptome of >16,000 Tregs obtained from peripheral blood and synovial fluid of two patients with HLA-B27+ ankylosing spondylitis and three patients with psoriatic arthritis, closely related forms of inflammatory spondyloarthritis. We identify multiple Treg clusters with dist ...[more]