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The Pdx1 Cistrome of Pancreatic Islets

ABSTRACT: We performed global location analysis of Pdx1 occupancy in mouse and human islets.

ORGANISM(S): Mus musculus

SUBMITTER: Cynthia Khoo

PROVIDER: E-MTAB-1143 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Research resource: the pdx1 cistrome of pancreatic islets.

Khoo Cynthia C Yang Juxiang J Weinrott Samuel A SA Kaestner Klaus H KH Naji Ali A Schug Jonathan J Stoffers Doris A DA

Molecular endocrinology (Baltimore, Md.) 20120209 3

The homeodomain transcription factor pancreas duodenal homeobox 1 (Pdx1, also known as insulin promoter factor 1) is a master regulator of pancreas development, as mice or humans lacking Pdx1 function are a pancreatic. Importantly, heterozygous mutations in Pdx1 cause early and late onset forms of diabetes in humans. Despite these central roles in development and adult β-cell function, we have only rudimentary knowledge of the transcriptome targets of Pdx1 that mediate these phenotypes. Therefor ...[more]

PMID: 22322596

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