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Transcription profiling of the islets from Pdx1+/- mice compared to islets isolated from Pdx1 +/+ littermates

ABSTRACT: The aim of this experiment was to use global gene expression profiling to identify genes that are differentially expressed in the islets from Pdx1+/- mice compared to islets isolated from Pdx1 +/+ littermates. The Pdx1 null mutation consists of a nuclear targeted _-galactosidase cassette fused in-frame with the N terminus of PDX-1.

ORGANISM(S): Mus musculus

SUBMITTER: Mira Sachdeva

PROVIDER: E-MTAB-127 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress.

Sachdeva Mira M MM Claiborn Kathryn C KC Khoo Cynthia C Yang Juxiang J Groff David N DN Mirmira Raghavendra G RG Stoffers Doris A DA

Proceedings of the National Academy of Sciences of the United States of America 20091023 45

Type 2 diabetes mellitus (T2DM) results from pancreatic beta cell failure in the setting of insulin resistance. Heterozygous mutations in the gene encoding the beta cell transcription factor pancreatic duodenal homeobox 1 (Pdx1) are associated with both T2DM and maturity onset diabetes of the young (MODY4), and low levels of Pdx1 accompany beta cell dysfunction in experimental models of glucotoxicity and diabetes. Here, we find that Pdx1 is required for compensatory beta cell mass expansion in r ...[more]

PMID: 19855005

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