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Enhanced capacity to dissipate body heat alters mammary gene expression in lactating mice


ABSTRACT: The experiment was performed on 10 lactating laboratory mice (Mus musculus, MF1). Half of the mice were shaved to increase their capacity to dissipate body heat (and thus milk production), while the other half were unshaved controls. By RNA-seq profiling of the mammary gland in shaved and unshaved lactating mice, we identified differentially expressed genes (DEGs) associated with shaving and then compared them with three sets of genes compiled from the mouse mammary gland literature, containing 1) imprinted genes, 2) milk synthesis-related genes, and 3) involution-related genes. Finally, DEGs induced by shaving were subjected to functional analysis of gene expression, with the focus on canonical pathways, upstream regulators, and downstream effects. We demonstrated that the shaving-induced increases in milk production were not associated with the changes in the expression of imprinted or milk-synthesis related genes. Instead, several lines of evidence strongly suggest that the mammary gland of shaved mice went into involution earlier than that of unshaved mice. Our interpretation of these results is that once provided with the enhanced capacity to dissipate body heat, shaved mice were able to rear their young to independence faster than unshaved mothers, benefiting potentially from shorter lactation and shorter interbirth interval to maximise their lifetime reproductive success.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Mus musculus

SUBMITTER: Elzbieta Krol 

PROVIDER: E-MTAB-11654 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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