Browse
Submit Data
Databases
API
Help

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA sequencing of control and Gprc5c overexpression in MLL-AF9 leukemia mice

ABSTRACT: The transcriptome of Gprc5c overexpression and control in the context of MLL-AF9 leukemia in mice was assessed by RNAseq.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Mus musculus

SUBMITTER: Mari Carmen Romero-Mulero

PROVIDER: E-MTAB-11690 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

RNA Sequencing of Gprc5c-Knockout (Gprc5c-KO) and wildtype (WT) control mice HSCs.

Project description:The transcriptome of Gprc5c-KO and WT control mice HSCs were assessed by RNA-seq.

2022-04-06 | E-MTAB-9862 | biostudies-arrayexpress

RNA sequencing of control and GPRC5C-Overexpression (GPRC5C-OE) in human mobilized peripheral blood (mPB)

Project description:The human transcriptome of lentiviral GPR-OE and control was assessed by RNAseq.

2022-04-06 | E-MTAB-9874 | biostudies-arrayexpress

RNA Sequencing of LT-HSCs and ST-HSCs from healthy adult human Bone Marrow

Project description:The transcriptome of LT-HSC (CD34+CD38-CD45RA+CD90+CD49f+) and ST-HSC (CD34+CD38-CD45RA+CD90-CD49f-) from healthy adult human Bone Marrow Cells were assessed by RNA-seq.

2022-04-06 | E-MTAB-9892 | biostudies-arrayexpress

Population RNA Seq of human HSPCs (Lineage negative, CD38 negative, CD34 positive) of control patients or myocardial infarction patients and treated with at-RA/4-oxo-RA/DMSO for 72h in culture

Project description:Study of the transcriptomic changes in human HSPCs under the influence of at-RA and 4-oxo-RA. Human Hematopoietic Stem and Progenitor Cells (HSPCs)(Lineage negative, CD38 negative, CD34 positive cells) were isolated from sternal bone marrow of patients who had experienced myocardial infarction or from control patients. For in vitro cultivation, cells were treated with at-RA (2.5 μM final concentration), 4-oxo-RA (2.5 μM final concentration), or the respective volume of DMSO (control) for 72 hours. After incubation period, cells were harvested for RNA extraction.

2025-02-06 | E-MTAB-13508 | biostudies-arrayexpress

Population RNA Seq of enriched human peripheral blood monocytes treated with at-RA/4-oxo-RA/DMSO for 24h in culture

Project description:Study of the effects of at-RA and 4-oxo-RA 72h treatment on the transcriptome of human peripheral blood monocytes from healthy individuals.

2025-02-06 | E-MTAB-14660 | biostudies-arrayexpress

RNA Seq of 7-month old control and Cyp26b1KO LT-HSCs

Project description:The transcriptome of Ctrl and Cyp26b1KO longterm hematopoietic stem cells (LT-HSC) of 7-month old mice was assessed by RNAseq.

2021-11-02 | E-MTAB-10659 | biostudies-arrayexpress

RNA Seq of control and Cyp26b1 knockout mouse longterm hematopoietic stem cells

Project description:The transcriptome of Ctrl and Cyp26b1KO longterm hematopoietic stem cells (LT-HSC) was assessed by RNAseq.

2021-11-02 | E-MTAB-9745 | biostudies-arrayexpress

Population RNA Seq of long-term HSCs isolated from mice after myocardial infarction (day 2 post infarct) or sham surgery and at-RA treatment or DMSO control treatment

Project description:Study of the effects of at-RA treatment on the transcriptome of murine Long-Term Hematopoietic Stem Cells (LT-HSCs) in the context of myocardial infarction (MI). MI was induced in female C57BL/6J mice aged 6 to approximately 12 weeks through permanent occlusion of the left anterior descending artery (LAD). Mice were intraperitoneally injected on the 1st and 2nd day after MI surgery with either 30 mg/kg body weight at-RA (Sigma-Aldrich; MI+at-RA condition), or with the corresponding amount of DMSO in phosphate-buffered saline (PBS) (MI+vehicle condition). Two days after MI, LT-HSCs (Lin-negative, Sca1-positive, c-Kit-positive, CD150-positive, CD48-negative, CD34-negative) were isolated from the bone marrow, sorted, and analyzed for their transcriptome profiles. This study aimed to understand how at-RA treatment influences gene expression in LT-HSCs following MI.

2025-02-06 | E-MTAB-13506 | biostudies-arrayexpress

RNA Seq of wildtype and Rarb KO HSCs after 24h of in vitro culture and treatment

Project description:The transcriptome of WT and Rarb KO hematopoietic stem cells (HSC) after 24h in vitro culture upon retinoid treatment was assessed by RNAseq.

2021-11-02 | E-MTAB-9749 | biostudies-arrayexpress

Population RNA Seq of cardiac fibroblasts, cardiac endothelial cells, cardiac monocytes, cardiac macrophages - isolated from mice after at-RA treatment or 4-oxo-RA or DMSO control treatment (24h post injection)

Project description:Study of the gene expression patterns of specific cardiac cell populations, including monocytes (CD45+, CD11b+, F4/80-, LyC6+), endothelial cells (CD45-, CD31+), macrophages (CD45+, CD11b+, F4/80+, LyC6-), and fibroblasts (CD45-, GP38+), in response to at-RA and 4-oxo-RA treatments. Female C57BL/6J mice aged 12 weeks were intraperitoneally injected with 30 mg/kg body weight at-RA (Sigma-Aldrich), 30 mg/kg body weight 4-oxo-RA (Sigma-Aldrich), or an equivalent volume of DMSO in phosphate-buffered saline (PBS) as the vehicle control. After 24 hours of injection, the mice were euthanized for analysis.

2025-02-06 | E-MTAB-13505 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data