Unknown,Transcriptomics,Genomics,Proteomics

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DNA methylation and gene expression analyses in adipose tissue to identify new loci associated with T2D development in obesity


ABSTRACT: Our study seeked to identify changes in DNA methylation and gene expression that might underlie type 2 diabetes susceptibility. We investigated DNA methylation and gene expression in VAT biopsies from 19 women with obesity, without (n=9) or with T2D (n=10). We analyzed and compared the methylome and transcriptome of visceral adipose tissue biopsies of women with obesity, with and without type 2 diabetes. Differential methylation and expression where then paired to test for Pearson's correlation to measure their relationship.

ORGANISM(S): Homo sapiens

SUBMITTER: Francisco Barajas 

PROVIDER: E-MTAB-11841 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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