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Transcription profiling by array of changes produced in Brucella abortus by erythriyol

ABSTRACT: RNA from B. abortus 2308 grown in BB or BB+ erythritol, was labelled and hybridized with the ORFeome microarray to determine transcriptional changes produced by erythritol

ORGANISM(S): Brucella abortus

SUBMITTER: Juan Garcia Lobo

PROVIDER: E-MTAB-1189 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Evaluation of the effects of erythritol on gene expression in Brucella abortus.

Rodríguez María Cruz MC Viadas Cristina C Seoane Asunción A Sangari Félix Javier FJ López-Goñi Ignacio I García-Lobo Juan María JM

PloS one 20121214 12

Bacteria of the genus Brucella have the unusual capability to catabolize erythritol and this property has been associated with their virulence mainly because of the presence of erythritol in bovine foetal tissues and because the attenuated S19 vaccine strain is the only Brucella strain unable to oxydize erythritol. In this work we have analyzed the transcriptional changes produced in Brucella by erythritol by means of two high throughput approaches: RNA hybridization against a microarray contain ...[more]

PMID: 23272076

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