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CD8 T cells stimulation with high grade serous ovarian carcinoma ascites

ABSTRACT: Ovarian cancer is the most lethal gynecological malignancy with approximately 60.000 new cases annually in the United States and the European Union. Several observations indicate that the immune system plays a crucial role in ovarian cancer. Thus, an increased accumulation of intratumoral T cells delays recurrence of the disease. Among infiltrating T cells, CD8+ T cells are associated with a better prognosis. However, the ovarian cancer environment impairs the anti-tumor function of CD8+ T cells through inhibitory signaling pathways. Then we stimulated CD8+ T cells from healthy donors by ascites samples from different clinical patients for 16hr.

INSTRUMENT(S): NextSeq 550

ORGANISM(S): Homo sapiens

SUBMITTER:

PROVIDER: E-MTAB-12141 | biostudies-arrayexpress |

SECONDARY ACCESSION(S): ERP140775

REPOSITORIES: biostudies-arrayexpress

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