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Remodeling of cell-type specific transcriptomes upon T cell stimulation in Systemic lupus erythematosus versus Sjögren’s syndrome

ABSTRACT: The RNA-sequencing to profile patient peripheral blood mononuclear cell (PBMC) samples of systemic lupus erythematosus (SLE, N=25), primary Sjögren’s syndrome (pSS, N=23), and healthy control (HD, N=24). We collected on the steady-state and 18-hours anti-CD3 culture to identify the transcriptome remodeling upon T-cell stimulation. Each patient samples were sorted for CD4+ (Th cells) and CD8+ (CTL) T lymphocytes, CD16+CD7+ cells (NK cells), and CD19+ cells (B cells).

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Homo sapiens

SUBMITTER: Gino Kwon

PROVIDER: E-MTAB-12203 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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