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Effects of doxorubicin dosages on gene copy number variations in MCF-7 cell line

ABSTRACT: Anti-cancer drugs, particularly doxorubicin may trigger alterations in the copy numbers of genes. The data present the results of array comperative genomic hybridization of two different MCF-7 cell lines that are resistant to diverse concentration of the doxorubicin in the presence of the sentive control. Although the submission options were chosen as SurePrint G3 Human CGH Microarray 8x60K (G4450A; Agilent Technologies, USA) for all data, a resistant cell line, so called aCGH_400DOX, was studied by the GenetiSure Cyto 8 x 60K CGH Microarrays (G5982A; Agilent Technologies, USA). The results underlined that resistance to the doxorubicin at diverse drug dosages critically altered the copy numbers of some of the fundamental genes.

ORGANISM(S): Homo sapiens

SUBMITTER: hasan huseyin kazan

PROVIDER: E-MTAB-12232 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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