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A single cell atlas of frozen shoulder capsule identifies features associated with inflammatory fibrosis resolution

ABSTRACT: Single cell transcriptomic data of shoulder capsule from foetal, adult comparator (normal) and frozen shoulder (disease).

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Ng

PROVIDER: E-MTAB-12304 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A single cell atlas of frozen shoulder capsule identifies features associated with inflammatory fibrosis resolution.

Ng Michael T H MTH Borst Rowie R Gacaferi Hamez H Davidson Sarah S Ackerman Jessica E JE Johnson Peter A PA Machado Caio C CC Reekie Ian I Attar Moustafa M Windell Dylan D Kurowska-Stolarska Mariola M MacDonald Lucy L Alivernini Stefano S Garvilles Micon M Jansen Kathrin K Bhalla Ananya A Lee Angela A Charlesworth James J Chowdhury Rajat R Klenerman Paul P Powell Kate K Hackstein Carl-Philip CP Furniss Dominic D Rees Jonathan J Gilroy Derek D Coles Mark M Carr Andrew J AJ Sansom Stephen N SN Buckley Christopher D CD Dakin Stephanie G SG

Nature communications 20240219 1

Frozen shoulder is a spontaneously self-resolving chronic inflammatory fibrotic human disease, which distinguishes the condition from most fibrotic diseases that are progressive and irreversible. Using single-cell analysis, we identify pro-inflammatory MERTK<sup>low</sup>CD48<sup>+</sup> macrophages and MERTK + LYVE1 + MRC1+ macrophages enriched for negative regulators of inflammation which co-exist in frozen shoulder capsule tissues. Micro-cultures of patient-derived cells identify integrin-med ...[more]

PMID: 38374174

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