Transcriptional and epigenetic high throughput sequencing of human and mouse pancreatic islet-cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jorge Ferrer
PROVIDER: E-MTAB-1294 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes.
Morán Ignasi I Akerman Ildem I van de Bunt Martijn M Xie Ruiyu R Benazra Marion M Nammo Takao T Arnes Luis L Nakić Nikolina N García-Hurtado Javier J Rodríguez-Seguí Santiago S Pasquali Lorenzo L Sauty-Colace Claire C Beucher Anthony A Scharfmann Raphael R van Arensbergen Joris J Johnson Paul R PR Berry Andrew A Lee Clarence C Harkins Timothy T Gmyr Valery V Pattou François F Kerr-Conte Julie J Piemonti Lorenzo L Berney Thierry T Hanley Neil N Gloyn Anna L AL Sussel Lori L Langman Linda L Brayman Kenneth L KL Sander Maike M McCarthy Mark I MI Ravassard Philippe P Ferrer Jorge J
Cell metabolism 20121001 4
A significant portion of the genome is transcribed as long noncoding RNAs (lncRNAs), several of which are known to control gene expression. The repertoire and regulation of lncRNAs in disease-relevant tissues, however, has not been systematically explored. We report a comprehensive strand-specific transcriptome map of human pancreatic islets and β cells, and uncover >1100 intergenic and antisense islet-cell lncRNA genes. We find islet lncRNAs that are dynamically regulated and show that they are ...[more]
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