The effects of prostaglandin E2 on the gene expression of human natural killer cells
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ABSTRACT: Tumour immune escape is a major factor contributing to cancer progression and unresponsiveness to cancer therapies. Tumours can produce prostaglandin E2 (PGE2), an inflammatory mediator that directly acts on NK cells to inhibit anti-tumour immunity. However, it is unclear precisely how PGE2 influences NK cell tumour-restraining functions. Here, we investigated how treatment with PGE2 over 24 hours affects gene expression in human NK cells.
INSTRUMENT(S): Illumina NovaSeq 6000
ORGANISM(S): Homo sapiens
SUBMITTER: Ian Donaldson
PROVIDER: E-MTAB-13106 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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