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RNA-seq bulk of CCR6+Th-cell subsets in Crohn’s Disease, peripheral blood and intestinal lamina propria

ABSTRACT: This RNA seq experiment was designed to identify a gene signature of a CCR5-expressing subset of human intestinal Th17-cells. T helper-cells from peripheral blood of healthy donors and from the lamina propria of Crohn’s Disease patients were FACS-purified according to the expression of the chemokine receptors CCR6, CCR5 and CXCR3. Four CCR6+Th- subsets were isolated according to CXCR3 and CCR5 expression: two CXCR3- Th17 subsets (CCR5-: “cTh17” or CCR5+: “pTh17”) and two subsets of CXCR3+ Th1/17-cells (CCR5+ or CCR5-)

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Homo sapiens

SUBMITTER: Valeria Ranzani

PROVIDER: E-MTAB-13178 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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