Unknown,Transcriptomics,Genomics,Proteomics

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Identification of potential miR-31 target-genes in Ewing Sarcoma

ABSTRACT: We identified miR-31 as strongest downregulated miRNA in the bone tumor Ewing sarcoma. To identify miR-31 targets in ES genome-wide gene expression profiles of TC71 cells transfected with miR-31 mimics or negative control (Life Technologies) generated in three independent experiments (a, b, c). Total RNA was isolated from cells after 72 h incubation in serum-reduced medium (1% FCS) and three transfections. Fifteen upregulated and 14 downregulated genes were detected with a 2 fold change cut-off (FDR <0.05).

ORGANISM(S): Homo sapiens

SUBMITTER: Bianca Karnuth 

PROVIDER: E-MTAB-1334 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Differentially expressed miRNAs in Ewing sarcoma compared to mesenchymal stem cells: low miR-31 expression with effects on proliferation and invasion.

Karnuth Bianca B   Dedy Nicolas N   Spieker Tilmann T   Lawlor Elizabeth R ER   Gattenlöhner Stefan S   Ranft Andreas A   Dirksen Uta U   Jürgens Heribert H   Bräuninger Andreas A  

PloS one 20140325 3

Ewing sarcoma, the second most common bone tumor in children and young adults, is an aggressive malignancy with a strong potential to metastasize. Ewing sarcoma is characterised by translocations encoding fusion transcription factors with an EWSR1 transactivation domain fused to an ETS family DNA binding domain. microRNAs are post-transcriptional regulators of gene expression and aberrantly expressed microRNAs have been identified as tumor suppressors or oncogenes in most cancer types. To identi  ...[more]

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