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A primate nigrostriatal atlas of neuronal vulnerability and resilience in a model of Parkinson’s disease

ABSTRACT: The degenerative process in Parkinson’s disease (PD) causes a progressive loss of dopaminergic neurons (DaNs) in the nigrostriatal system. Resolving the differences in neuronal susceptibility warrants an amenable PD model that, in comparison to post-mortem human specimens, controls for environmental and genetic differences in PD pathogenesis. At present study, we generated a primate model of PD by carotid artery injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine MPTP and sampled substantia nigra and putamen of macaque for single cell sequencing analysis.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Macaca fascicularis

SUBMITTER: Sheng Liu 

PROVIDER: E-MTAB-13437 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A primate nigrostriatal atlas of neuronal vulnerability and resilience in a model of Parkinson's disease.

Tang Lei L   Xu Nana N   Huang Mengyao M   Yi Wei W   Sang Xuan X   Shao Mingting M   Li Ye Y   Hao Zhao-Zhe ZZ   Liu Ruifeng R   Shen Yuhui Y   Yue Feng F   Liu Xialin X   Xu Chuan C   Liu Sheng S  

Nature communications 20231118 1

The degenerative process in Parkinson's disease (PD) causes a progressive loss of dopaminergic neurons (DaNs) in the nigrostriatal system. Resolving the differences in neuronal susceptibility warrants an amenable PD model that, in comparison to post-mortem human specimens, controls for environmental and genetic differences in PD pathogenesis. Here we generated high-quality profiles for 250,173 cells from the substantia nigra (SN) and putamen (PT) of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (  ...[more]

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