Transcriptome analysis of fission yeast silencing mutants
Ontology highlight
ABSTRACT:
ORGANISM(S): Schizosaccharomyces pombe
SUBMITTER: Hiroaki Kato
PROVIDER: E-MTAB-1373 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Spt6 prevents transcription-coupled loss of posttranslationally modified histone H3.
Kato Hiroaki H Okazaki Kosuke K Iida Tetsushi T Nakayama Jun-Ichi J Murakami Yota Y Urano Takeshi T
Scientific reports 20130101
The tail of histone H3 is an ideal medium for storing epigenetic information because displacement of histone H3 is heavily restricted during transcription. To maintain the locus-specific modifications of histone H3, histone molecules should be retained locally at the original position through multiple rounds of transcription. Here, we found that fission yeast Spt6, a highly conserved RNA polymerase II-interacting histone H3-H4 chaperone, is essential for the maintenance of Lys-4 and Lys-9 methyl ...[more]
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