Transcription profiling of mouse beta cells lacking NeuroD
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ABSTRACT: The goal: Investigate NeuroD function in the mature beta cells. The model: Cross RIP-Cre to NeuroD flox/flox mouse to delete neuroD when insulin gene is activated; The methods: Islets are purified and RNA is extracted to see how the profile of gene expression is altered after neuroD is deleted from the beta cells. The comparison: Compare control with mutant; The hypothesis: Since neuroD is deleted, I would expect that neuroD mRNA will be decreased in the mutant samples; The samples: two types of samples will be submitted including control and conditional knockout (mutant); Flox/+,Ins (F/+,I) is the control and labled as group B; and Flox/-,Ins (F/-,I) is the conditional knockout and labled as group A
ORGANISM(S): Mus musculus
SUBMITTER: Chunyan Gu
PROVIDER: E-MTAB-152 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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