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IGR_BREAST_EXON_AGILENT_STUDY_FA

ABSTRACT: We profiled breast cancer samples with exon arrays (244K Agilent Human exon) in order to identify exons associated with higher risk of relapse. This set contain 178 single dual color of samples (biopsies) versus normal breast reference (Normal breast Clontech) , 5 dye-swap (10 hybridizations) and 5 self self for controls.

ORGANISM(S): Homo sapiens

DISEASE(S): breast adenocarcinoma

SUBMITTER: Philippe DESSEN

PROVIDER: E-MTAB-1389 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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ATIP3, a novel prognostic marker of breast cancer patient survival, limits cancer cell migration and slows metastatic progression by regulating microtubule dynamics.

Molina Angie A Velot Lauriane L Ghouinem Lydia L Abdelkarim Mohamed M Bouchet Benjamin Pierre BP Luissint Anny-Claude AC Bouhlel Imène I Morel Marina M Sapharikas Elène E Di Tommaso Anne A Honoré Stéphane S Braguer Diane D Gruel Nadège N Vincent-Salomon Anne A Delattre Olivier O Sigal-Zafrani Brigitte B André Fabrice F Terris Benoit B Akhmanova Anna A Di Benedetto Mélanie M Nahmias Clara C Rodrigues-Ferreira Sylvie S

Cancer research 20130208 9

Metastasis, a fatal complication of breast cancer, does not fully benefit from available therapies. In this study, we investigated whether ATIP3, the major product of 8p22 MTUS1 gene, may be a novel biomarker and therapeutic target for metastatic breast tumors. We show that ATIP3 is a prognostic marker for overall survival among patients with breast cancer. Notably, among metastatic tumors, low ATIP3 levels associate with decreased survival of the patients. By using a well-defined experimental m ...[more]

PMID: 23396587

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