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Nuclear calcium regulated genes in spinal neurons during inflammatory pain

ABSTRACT: Identification of a pain-associated, nuclear calcium-regulated gene program in spinal excitatory neurons during inflammatory pain, using a nucleus-specific calcium signal perturbation strategy in vivo complemented by gene profiling

ORGANISM(S): Mus musculus

SUBMITTER: Manuela Simonetti

PROVIDER: E-MTAB-1416 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Nuclear calcium signaling in spinal neurons drives a genomic program required for persistent inflammatory pain.

Simonetti Manuela M Hagenston Anna M AM Vardeh Daniel D Freitag H Eckehard HE Mauceri Daniela D Lu Jianning J Satagopam Venkata P VP Schneider Reinhard R Costigan Michael M Bading Hilmar H Kuner Rohini R

Neuron 20130101 1

Persistent pain induced by noxious stimuli is characterized by the transition from normosensitivity to hypersensitivity. Underlying mechanisms are not well understood, although gene expression is considered important. Here, we show that persistent nociceptive-like activity triggers calcium transients in neuronal nuclei within the superficial spinal dorsal horn, and that nuclear calcium is necessary for the development of long-term inflammatory hypersensitivity. Using a nucleus-specific calcium s ...[more]

PMID: 23312515

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